The Wayne County Historical Museum is in the Rollie Ley mansion, also known as the Wightman House, at 702 Lincoln Street, which was listed on the National Register of Historic Places in 1978.

Wayne County Treasurer — property taxes, motor vehicle registrations, and county financial services in Wayne County, Nebraska.

The Wayne County Weed Superintendent enforces Nebraska's Noxious Weed Control Act — annual land inspections, eradication programs, and landowner education.

Wayne Elementary School serves preschool through grade 6.

The Wayne Herald is a Published since the 1880s.

Wayne Historical Marker stands in Henry Victor Park facing South Main Street (Highway 15), 0.1 mile south of Clark Street in Wayne.

Wayne Motors is a used car dealer at 315 South Main Street in Wayne, started in 1995 and run by the Bebee family.

The Wayne Municipal Auditorium at 222 North Pearl Street is an Art Deco building built in 1935 as a Public Works Administration project and listed on the National Register of Historic Places in 2002.

The Wayne Police Department serves the City of Wayne, with a non-emergency number of (402) 375-2626; call 911 for emergencies.

Wayne Public Library, the public library serving Wayne, Nebraska.