The High Plains Agricultural Laboratory is a 2,410-acre University of Nebraska research farm six miles north of Sidney on Highway 385, in Cheyenne County — about 710 acres of crop land in seventeen fields and 1,700 acres of pasture in twelve pastures. It runs 50 to 60 trials a year in agronomy, plant breeding, plant pathology, soil fertility, irrigation, entomology, weed science, agricultural economics and livestock nutrition, and holds an annual field day.

High Plains Homestead, a history and heritage museum in Crawford, Nebraska.

High Point RV Park in Kimball, Nebraska.

Independent insurance agency in Red Cloud, Webster County, formerly GTA Insurance Group.

The Grand Island office of Highstreet Insurance Services, an independent agency with a strong agricultural emphasis.

The last landing on the Niobrara National Scenic River, at the Highway 137 bridge north of Newport. Damaged in 2019; check before you go.